Blue Stone Co., Ltd.

Open the door to a healthy tomorrow.
We specialize in medical care, beauty, and health.
I will take this seriously.

Created by exosomes
Future medical care.

We offer advanced treatments and beauty protocols that utilize exosomes to maximize cellular resilience, coordinating effective and sustainable results tailored to your individual needs. Our vision is to help our patients and customers feel satisfied, confident and enjoy healthy lives.
exosome
EXOSOME

What are exosomes?

The human body is made up of elements called "cells." There are finer substances inside each cell, one of which is exosomes. Exosomes are extremely small substances released by cells, and are like ``capsules filled with various things inside.''

The existence of exosomes has been known for a long time, but they were thought to be like ``trash cans'' in which cells encapsulate things they no longer need and release them. However, in 2007, it was reported that these capsules contain genetic information called miRNA (microRNA), which led to rapid research into exosomes as a substance that plays an important role as a communication tool between cells. It attracted the attention of people.

``Exosomes'' are not the same type of beauty ingredients as ``hyaluronic acid,'' for example. The original "definition" of "exosome" is a concept as big as the word "cell."

As mentioned earlier, exosomes "have various effects on the whole body," so they can be expected to have multifaceted effects.

Maximize effectiveness by combining active ingredients in a well-balanced manner

There are various factors that cause our daily physical condition to change.
Therefore, we investigated the imbalance in growth factors and exosomes secreted from stem cells at each individual site.
We have achieved a well-balanced combination of rare growth factors and exosomes.

Effects of exosomes

Exosomes are expected to have anti-inflammatory, immunoregulatory, tissue repair, and anti-aging functions.
Exosomes have the effect of promoting and regulating skin turnover, and can be expected to have positive effects on all skin problems.
Skin problems such as dry skin are caused by disturbed skin turnover and decreased barrier function, but exosomes can repair and improve these functions and are thought to be effective in maintaining healthy and beautiful skin.
More specific actions and functions are gradually being elucidated, such as anti-inflammatory effects, immunoregulatory effects, tissue repair effects, and anti-aging functions, and they are expected to be used in the medical and cosmetic fields.

dermatitis treatment

Dermatitis Part 1 Before and after treatment
Dermatitis Part 2 Before and after treatment

beauty skin regeneration
(Improves stains, wrinkles, and sagging)

Improvement of sagging
beauty skin regeneration (Sagging improvement) Before and after treatment
Wrinkle improvement
beauty skin regeneration (Wrinkle improvement) Before and after treatment
Improvement of nasolabial folds
beauty skin regeneration (Improvement of nasolabial folds) Before and after treatment
Improvement of bags under the eyes
beauty skin regeneration (Improvement of bags under the eyes) Before and after treatment

hair growth treatment

Before and after hair growth treatment

Safety of exosomes

Exosomes are expected to be a relatively safe treatment with fewer side effects.
Exosomes are expected to be a relatively safe treatment, with fewer side effects than other treatments. It is derived from human cells and is said to have a low risk of causing toxicity or rejection reactions to the body.
Made in Japan for peace of mind
Made in Japan for peace of mind
Manufactured at our own cell processing facility in Japan. The stem cells we use are adipose-derived stem cells and amniotic membrane-derived stem cells collected from healthy Japanese female donors in their 20s to 30s in a clean room. These stem cells are used with the consent of the donor and their origin is clearly documented.
Various tests have been conducted
Various tests have been conducted
During the process from cultivation to manufacturing, we conduct quality checks such as stem cell tests, mycoplasma tests, sterility tests, and endotoxin tests to confirm that there are no problems.
Conduct the test
Conduct the test
We conduct tests on each manufacturing lot to confirm the exosome concentration, and only ship those that meet internal standards.
Safety management/quality assurance system
Safety management/quality assurance system
We have facilities and environments that comply with GMP grade, from raw material procurement and equipment management to facility maintenance and manufacturing processes.

What is stem cell culture supernatant?

Stem cells are cells that have the ability to regenerate the human body. Although it is used in regenerative medicine treatment, the number of patients who can receive treatment is limited due to high hurdles such as cost and risk. Under such circumstances, "human stem cell culture supernatant liquid" has attracted attention.
Human stem cell culture supernatant is a culture supernatant obtained by removing stem cells from the medium used to culture human-derived stem cells. It is known that various active ingredients (growth factors, exosomes, etc.) are secreted into the culture supernatant, and numerous effects have been reported in the medical and beauty fields.
Human stem cell culture supernatant

Precautions after exosome treatment
(This product is not a pharmaceutical product)

  1. Although it is said that there is no need to worry about allergies, some people may experience allergic symptoms.
    If you have had an allergy to culture supernatant in the past, you generally cannot undergo the treatment.
  2. Even if you have had no problems with past use, you may experience side effects depending on your physical condition that day.
    If you notice any changes, please contact your local hospital immediately.
  3. Please note that those who have received exosomes even once will not be able to donate blood for three months.
    *According to Japanese Red Cross Society regulations, it is possible to receive blood transfusions.
  4. For safety reasons, those who are pregnant or may become pregnant cannot undergo the treatment.
    *On the day of treatment
  5. In effect there are individual differences.

What is NMN?

NMN is NMN (nicotinamide mononucleotide).
In recent years, it is an ingredient that has attracted attention in fields focused on beauty, health, and rejuvenation.
NMN (Nicotinamide mononucleotide) is one of the components belonging to the vitamin B group, and is present in the body of humans and many other organisms.
NMN turns into NAD in the body. NAD is a substance that is involved in maintaining youth and health. When NAD increases, NAD activates sirtun (rejuvenation gene).
NAD peaks in the late teens and declines, and by the age of 40 it has decreased to about half of its peak.
Intravenous drip therapy is the best way to efficiently take NMN into the body. Supplements are also convenient because they are affordable and can be taken daily.

What is “NMN drip”?

NMN drip
NMN drip is a next-generation anti-aging therapy that is attracting worldwide attention and has been discovered to have a rejuvenating effect through research at Harvard Medical School. It has an activating effect.
NMN (nicotinamide mononucleotide) is a vitamin-like substance that is naturally produced in the body and plays a role in repairing organs and tissues. It is thought that as NMN decreases with age, the human body's repair, physical, and cognitive functions decline, leading to the progression of aging.
By administering NMN directly into the body via NMN drip and activating sirtuin genes, various rejuvenating effects can be expected, such as improving physical and cognitive functions, recovering from fatigue, and maintaining physical health.

Effects of NMN drip

By activating longevity genes that influence rejuvenation and improving physical functions, we can expect three major effects: ``anti-aging,'' ``improving skin quality,'' and ``improving diseases and physical functions.''
Anti-aging/anti-aging
  • Improved concentration
  • Improvement of dementia
  • I can sleep soundly
  • Physical strength recovers more easily
  • Difficulty breathing during exercise
It is expected to be effective in reducing aging genes and improving the decline in motor function and cognitive function. It also has the effect of restoring breathing function, improving sleep quality and concentration.
Improvement of skin problems
  • Improved skin texture and firmness
  • Improvement of wrinkles and spots
  • Improves dullness, sagging, etc.
  • Increases skin moisture
By improving your metabolism, you can expect to have the effect of recovering from skin problems caused by aging.
Improvement of illness and physical function
  • Improved repair functionality
  • neurological disease
  • Eye diseases
  • Lifestyle-related diseases such as obesity and diabetes
  • Cardiovascular diseases such as arteriosclerosis and myocardial infarction
  • Dementia etc.
By improving metabolism and repair functions and strengthening immunity, we can expect recovery from various functional disorders and prevention and improvement of diseases.
Effects can be felt by “continuing”
Effects can be seen with a single treatment, but in order to experience the effects of anti-aging, improving skin quality, recovering from fatigue, maintaining health, etc., continuous administration once every 1 to 4 weeks is necessary. You can maintain the effect.
High purity and high quality NMN
NMN infusions are expensive, as are high-quality NMN supplements. For this reason, many people take NMN through low-priced supplements and are unable to feel the effects, which is why they complain that it is not effective.
There are cases where side effects may occur due to the ingredients contained in low-quality supplements, so be careful when taking cheap supplements.
In order to receive highly pure and high quality NMN, please consult with a specialist doctor before undergoing treatment.

Side effects of NMN infusion

There are almost no side effects, but vascular pain that occurs during infusion may occur.
Pain can be suppressed by extending the administration time.
Also, no serious side effects have been confirmed at this time.

NMN infusion is a new treatment method that is attracting attention worldwide, and it is thought that because awareness is low, many people are worried about side effects and safety, wondering if NMN is dangerous. .
Vascular pain has been reported as a side effect, but it subsides within a few days and is a symptom that can occur with all types of infusions, not just NMN infusions.
Judging from the current side effects, the risk of threatening health is low, and its safety for humans has been confirmed.

NMN drip is still undergoing clinical trials and research is progressing. If you would like to know the latest information about NMN drip or have any concerns, please feel free to consult your doctor.

Precautions for NMN drip

Please note that the following people will not be able to receive treatment.
  1. Pregnant women
  2. Those who are breastfeeding
  3. Those with a disease currently being treated
  4. Persons with neoplastic disease
  5. Persons with allergic diseases or drug allergies
Clarification that it is an unapproved drug, etc.
The gene used in NMN infusion is an uncertified drug that has not been approved under the Pharmaceutical and Medical Device Act. In Japan, unapproved medicines can be used at the responsibility of the doctor.
Clarification of the presence or absence of domestically approved drugs, etc.
There are currently no other domestically approved drugs that have the same performance as the one used for this treatment.
Clarification of information related to safety in other countries
There is no information regarding safety etc. in major European and American countries. In Japan, a research group at Keio University School of Medicine became the first in the world to demonstrate that NMN can be safely administered to humans. Additionally, there are no reports of serious side effects at this time.

What is “NMN supplement”?

NMN supplement
NMN supports the production of NAD+ in our bodies and is therefore deeply involved in energy production and cellular health. Additionally, it is said to slow down the aging process, and there is a lot of research going on in this regard.
NMN is a nutrient that is naturally produced in the body, and is said to be contained in very small amounts in vegetables such as broccoli, avocado, and edamame.
It is said that it is extremely difficult to intake enough NMN from food to satisfy your needs as it is only in very small amounts.
NMN and NAD in the body decrease with age, so for older people, taking NMN can be expected to have an anti-aging effect.

Effects of NMN intake

NAD+ is a component deeply involved in energy production and cell health in our bodies, but its amount decreases as we age.
The focus here is on NMN. NMN plays a role in supporting the production of NAD+ in the body.
Specifically, NMN acts as a precursor to NAD+ and can increase its amount. This is thought to help ensure smooth energy production and maintain cellular health. NAD+ is also associated with longevity genes and is thought to contribute to their activation.
Rejuvenation and anti-aging
Ingestion of NMN is expected to have the effect of slowing down the aging process.
Research has shown that administering NMN to mice alleviated age-related physical decline. Specifically, effects such as suppressing weight gain, improving energy metabolism, and improving insulin sensitivity were confirmed.
Based on these results, it is thought that NMN has a high possibility of contributing to the rejuvenation and anti-aging of our bodies.
NMN supplement: rejuvenation and anti-aging
Improving muscle strength and motor function
Research is progressing on improving muscle strength and motor function through the intake of NMN.
Fatigue is thought to be caused by a decline in energy metabolism, but it is believed that ingesting NMN activates mitochondria and improves energy metabolism.
This may reduce muscle weakness and fatigue during exercise.
There are also reports that ingesting NMN improves sleep quality. These effects are expected to improve the quality of daily life and sports performance.
NMN supplement: Improving muscle strength and motor function

Safety of NMN supplements

NMN (nicotinamide mononucleotide) has been attracting attention as an anti-aging ingredient in Japan since around 2016.
However, many people have concerns and questions about its safety.

Many studies have been conducted on taking NMN supplements and have shown that taking NMN as a supplement is relatively safe.
In particular, there were no reports of serious side effects in a study in which the drug was taken continuously for 12 weeks (approximately 3 months).
However, there is still insufficient research on its use in combination with other medicines or its intake during pregnancy, so caution is required.
Choose high-quality supplements
There are many NMN supplement products on the market.
When choosing high-quality supplements, it is important to choose products that disclose the purity of their ingredients and products that are manufactured in GMP (Good Manufacturing Practice) certified factories.

Notes on NMN supplements

Clarification that it is an unapproved drug, etc.
The genes used in NMN supplements are uncertified pharmaceuticals that have not been approved under the Pharmaceutical and Medical Device Act. In Japan, unapproved medicines can be used at the responsibility of the doctor.
Clarification of the presence or absence of domestically approved drugs, etc.
There are currently no other domestically approved drugs that have the same performance as the one used for this treatment.
Clarification of information related to safety in other countries
There is no information regarding safety etc. in major European and American countries. In Japan, a research group at Keio University School of Medicine became the first in the world to demonstrate that NMN can be safely administered to humans. Additionally, there are no reports of serious side effects at this time.
MEDICAL CARE

Careful examination and diagnosis by advanced medical equipment and experienced doctors.
We will introduce you to various medical services that meet your needs.

  • Gastroenterology
  • Internal medicine online medical treatment
  • vaccination
  • Health checkup/Comprehensive medical checkup
  • Genome repair therapy (hair growth/hair growth)
  • Gastrocamera examination
  • Colon camera examination
  • Colon polyp day surgery

If you would like to receive medical treatment/examination, please visit this hospital.

1 minute walk from JR “Shinjuku Station” east exit “Shinjuku Gastroenterology Clinic”
Medical treatment without stress and anxiety “Shinjuku Gastroenterology Clinic”
Careful examination from the patient's perspective